Chronic inflammation affects the gut and can lead to colic!
“Inflammation is caused and sustained by immune cell infiltration in the intestinal mucosa, which determines tissue damage characterized by the loss of epithelial cells and degradation of the extracellular matrix in the lamina propria, leading to ulceration.”
https://www.horsetalk.co.nz/2022/12/15/spotlight-chronic-inflammation-recurrent-colic-horses/